Review




Structured Review

Chrom Tech chrom logd_v3.value
Information Around the in-House QSAR Models and Descriptors used to Build the Log%SDiP OPLS Model
Chrom Logd V3.Value, supplied by Chrom Tech, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/chrom+logd_v3%2Evalue/logd+v3+value/pmc05040732-167-57-58
Average 90 stars, based on 1 article reviews
chrom logd_v3.value - by Bioz Stars, 2026-09
90/100 stars

Images

1) Product Images from "Development of a Novel Quantitative Structure-Activity Relationship Model to Accurately Predict Pulmonary Absorption and Replace Routine Use of the Isolated Perfused Respiring Rat Lung Model"

Article Title: Development of a Novel Quantitative Structure-Activity Relationship Model to Accurately Predict Pulmonary Absorption and Replace Routine Use of the Isolated Perfused Respiring Rat Lung Model

Journal: Pharmaceutical Research

doi: 10.1007/s11095-016-1983-4

Information Around the in-House QSAR Models and Descriptors used to Build the Log%SDiP OPLS Model
Figure Legend Snippet: Information Around the in-House QSAR Models and Descriptors used to Build the Log%SDiP OPLS Model

Techniques Used: Permeability, Software, Binding Assay, Molecular Weight

Related Articles

Permeability:

Article Title: Development of a Novel Quantitative Structure-Activity Relationship Model to Accurately Predict Pulmonary Absorption and Replace Routine Use of the Isolated Perfused Respiring Rat Lung Model
Article Snippet: The contribution of each of the 20 descriptors and 6 ADME model outputs of the x variable block are shown in the regression coefficients plot in Fig. . Descriptors that positively correlate with Log%SDiP include: extent of absorption in the rat following oral administration (FA_rat_v1.logFA_score), permeability (perm_chrom_p.perm_score, MDCK2.Perm_pH74_nm_sec, MDCK2.Perm_pH64_nm_sec), substrates of the active efflux transporter Pgp (Pgp_v31.Pgp_Score), hydrophobicity (Chrom LogD_v3.value, logd_pH55_acd, logd_pH65_acd), and extent of compound residing in the neutral or unionised form (neutral_ionised_form).

Article Title: Development of a Novel Quantitative Structure-Activity Relationship Model to Accurately Predict Pulmonary Absorption and Replace Routine Use of the Isolated Perfused Respiring Rat Lung Model
Article Snippet: Chrom LogD_v3.value , An inhouse OPLS QSAR model that predicts hydrophobicity, the model was built on a GSK dataset of chromatographic hydrophobicity index (CHI) measurements ( ) which are converted to a chromLogD value ( ). , +.

Software:

Article Title: Development of a Novel Quantitative Structure-Activity Relationship Model to Accurately Predict Pulmonary Absorption and Replace Routine Use of the Isolated Perfused Respiring Rat Lung Model
Article Snippet: The contribution of each of the 20 descriptors and 6 ADME model outputs of the x variable block are shown in the regression coefficients plot in Fig. . Descriptors that positively correlate with Log%SDiP include: extent of absorption in the rat following oral administration (FA_rat_v1.logFA_score), permeability (perm_chrom_p.perm_score, MDCK2.Perm_pH74_nm_sec, MDCK2.Perm_pH64_nm_sec), substrates of the active efflux transporter Pgp (Pgp_v31.Pgp_Score), hydrophobicity (Chrom LogD_v3.value, logd_pH55_acd, logd_pH65_acd), and extent of compound residing in the neutral or unionised form (neutral_ionised_form).

Article Title: Development of a Novel Quantitative Structure-Activity Relationship Model to Accurately Predict Pulmonary Absorption and Replace Routine Use of the Isolated Perfused Respiring Rat Lung Model
Article Snippet: Chrom LogD_v3.value , An inhouse OPLS QSAR model that predicts hydrophobicity, the model was built on a GSK dataset of chromatographic hydrophobicity index (CHI) measurements ( ) which are converted to a chromLogD value ( ). , +.

Binding Assay:

Article Title: Development of a Novel Quantitative Structure-Activity Relationship Model to Accurately Predict Pulmonary Absorption and Replace Routine Use of the Isolated Perfused Respiring Rat Lung Model
Article Snippet: The contribution of each of the 20 descriptors and 6 ADME model outputs of the x variable block are shown in the regression coefficients plot in Fig. . Descriptors that positively correlate with Log%SDiP include: extent of absorption in the rat following oral administration (FA_rat_v1.logFA_score), permeability (perm_chrom_p.perm_score, MDCK2.Perm_pH74_nm_sec, MDCK2.Perm_pH64_nm_sec), substrates of the active efflux transporter Pgp (Pgp_v31.Pgp_Score), hydrophobicity (Chrom LogD_v3.value, logd_pH55_acd, logd_pH65_acd), and extent of compound residing in the neutral or unionised form (neutral_ionised_form).

Article Title: Development of a Novel Quantitative Structure-Activity Relationship Model to Accurately Predict Pulmonary Absorption and Replace Routine Use of the Isolated Perfused Respiring Rat Lung Model
Article Snippet: Chrom LogD_v3.value , An inhouse OPLS QSAR model that predicts hydrophobicity, the model was built on a GSK dataset of chromatographic hydrophobicity index (CHI) measurements ( ) which are converted to a chromLogD value ( ). , +.

Molecular Weight:

Article Title: Development of a Novel Quantitative Structure-Activity Relationship Model to Accurately Predict Pulmonary Absorption and Replace Routine Use of the Isolated Perfused Respiring Rat Lung Model
Article Snippet: The contribution of each of the 20 descriptors and 6 ADME model outputs of the x variable block are shown in the regression coefficients plot in Fig. . Descriptors that positively correlate with Log%SDiP include: extent of absorption in the rat following oral administration (FA_rat_v1.logFA_score), permeability (perm_chrom_p.perm_score, MDCK2.Perm_pH74_nm_sec, MDCK2.Perm_pH64_nm_sec), substrates of the active efflux transporter Pgp (Pgp_v31.Pgp_Score), hydrophobicity (Chrom LogD_v3.value, logd_pH55_acd, logd_pH65_acd), and extent of compound residing in the neutral or unionised form (neutral_ionised_form).

Article Title: Development of a Novel Quantitative Structure-Activity Relationship Model to Accurately Predict Pulmonary Absorption and Replace Routine Use of the Isolated Perfused Respiring Rat Lung Model
Article Snippet: Chrom LogD_v3.value , An inhouse OPLS QSAR model that predicts hydrophobicity, the model was built on a GSK dataset of chromatographic hydrophobicity index (CHI) measurements ( ) which are converted to a chromLogD value ( ). , +.

Blocking Assay:

Article Title: Development of a Novel Quantitative Structure-Activity Relationship Model to Accurately Predict Pulmonary Absorption and Replace Routine Use of the Isolated Perfused Respiring Rat Lung Model
Article Snippet: The contribution of each of the 20 descriptors and 6 ADME model outputs of the x variable block are shown in the regression coefficients plot in Fig. . Descriptors that positively correlate with Log%SDiP include: extent of absorption in the rat following oral administration (FA_rat_v1.logFA_score), permeability (perm_chrom_p.perm_score, MDCK2.Perm_pH74_nm_sec, MDCK2.Perm_pH64_nm_sec), substrates of the active efflux transporter Pgp (Pgp_v31.Pgp_Score), hydrophobicity (Chrom LogD_v3.value, logd_pH55_acd, logd_pH65_acd), and extent of compound residing in the neutral or unionised form (neutral_ionised_form).

Article Title: Development of a Novel Quantitative Structure-Activity Relationship Model to Accurately Predict Pulmonary Absorption and Replace Routine Use of the Isolated Perfused Respiring Rat Lung Model
Article Snippet: Chrom LogD_v3.value , An inhouse OPLS QSAR model that predicts hydrophobicity, the model was built on a GSK dataset of chromatographic hydrophobicity index (CHI) measurements ( ) which are converted to a chromLogD value ( ). , +.



Similar Products

Image Search Results